Health

 

Pp

Penn State study examines how a person's telomeres are affected by caloric restriction

A recent study by researchers at Penn State University has shed new light on the complex relationship between caloric restriction and telomeres, the protective caps at the ends of chromosomes that shorten with age. 

The study, published in the journal Aging Cell, analyzed data from the CALERIE trial, the first major randomized clinical trial on calorie restriction in humans. Researchers tracked the telomere length of 175 participants over a two-year period. 

Pp

Here's what they found: 

• Initial Telomere Loss: Contrary to expectations, participants on calorie-restricted diets initially lost telomeres at a faster rate than those on a standard diet. This suggests that caloric restriction might have short-term effects that accelerate cellular aging. 

• Slowed Telomere Loss After Stabilization: However, after a year, once the participants' weight stabilized, the rate of telomere loss in the calorie-restricted group slowed down significantly compared to the control group. This suggests potential long-term benefits for cellular health. 

Pp

• Similar Telomere Length at Study's End: Interestingly, despite the different trajectories, both groups ended the study with roughly the same telomere length. This indicates that the initial telomere loss might be compensated for by the later protective effects of caloric restriction. 

The study's findings highlight the complexities of how caloric restriction influences aging processes. While the initial telomere loss might seem concerning, the slowed rate in the later stages suggests potential benefits for long-term cellular health. 

This research paves the way for further investigation into the mechanisms behind these observations. Future studies could explore the underlying biological processes that cause the initial telomere loss and the later protective effects                

Readmore.... https://90aplusthenews.blogspot.com/2024/01/health.html?m=1

Overall, the Penn State study adds valuable insights to the ongoing research on caloric restriction and its potential impact on aging and cellular health.